Associate Director, ADME

The Role:

The Moderna DMPK team is looking for a talented, curious, and motivated scientist with a track record of DMPK support to projects across multiple disease areas and to contribute to refining the application of ADME and PK principles to this novel therapeutic modality. The successful candidate will set up an in-house ADME lab function, provide scientific input as the lead SME that applies DMPK expertise in a dynamic team setting to inform discovery and early development phase therapeutic LNP-mRNA project decisions and provides DMPK guidance to ensure successful candidate transition into clinical testing. Applicants should be self-starters with well-developed communication and influencing skills who have demonstrated direct and CRO team management and the ability to work effectively in a team driven, rapidly evolving, interactive scientific environment.



Here’s What You’ll Do:

Set up an in-house ADME function and in addition interact with CRO(s) to develop the ADME and IVIVE principles important to Moderna therapeutic modality development



Understand, use, and explain PK/ADME principles to inform and guide the design, assessment, and selection of clinically viable LNP-mRNA therapeutic candidates to discovery project teams



Effectively engage with the project representatives to inform and influence study/experimental design and project decisions, develop and execute ADME scientific plans, and critically review/assess quality of data and their suitability to inform project decisions



In collaboration with partner functions, devise and implement therapeutic ADME strategies



Actively engage with the DMPK team to increase understanding of and to communicate PK, ADME and DDI relevance to LNP-mRNA therapeutic development



Collaborate with and participate on platform activities and teams



Experience with LNPs, mRNA technology or other novel modalities is a plus



Experience with novel analytical technologies like ISH, sn(sc)-RNA seq, confocal microscopy, exosome sequencing, PCR techniques in addition to ADME experience is a plus



Here’s What You’ll Bring to the Table:

PhD in Pharmacy, Pharmacometrics, Chemistry, Biochemistry, or related field with 9+ years of BioPharma industrial experience, or, MS with 15+ years of experience in DMPK



Expertise in the application of DMPK and ADME principles and standard industry practices pertaining to PK, ADME, and DDI analysis



Familiarity with regulatory guidances as they pertain to DMPK and ADME discipline is a must



Excellent verbal and written communication skills



Experience with participation on multi-disciplinary teams



Experience with LNP, biomolecule, gene therapy, or mRNA therapeutics is a plus



Candidate will be diligent in documenting and communicating experimental methods/results, curious in exploring science to establish a new path for drug discovery/development and bold in proposing creative experimental designs and DMPK functional strategies. Will work collaboratively with multifunctional teams and will be relentless in transforming LNP-mRNA therapeutic scientific understanding while delivering successful clinical candidates.



Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

Highly competitive and inclusive medical, dental and vision coverage options

Flexible Spending Accounts for medical expenses and dependent care expenses

Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities

Family care benefits, including subsidized back-up care options and on-demand tutoring

Free premium access to fitness, nutrition, and mindfulness classes

Exclusive preferred pricing on Peloton fitness equipment

Adoption and family-planning benefits

Dedicated care coordination support for our LGBTQ+ community



Generous paid time off, including:

• Vacation, sick time and holidays


• Volunteer time to participate within your community


• D iscretionary year-end shutdown


• Paid sabbatical after 5 years; every 3 years thereafter

Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents

401k match and Financial Planning tools

Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options

Complimentary concierge service including home services research, travel booking, and entertainment requests

Free parking or subsidized commuter passes

Location-specific perks and extras!



Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible . Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.



About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.



Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com .



Moderna is a smoke-free, alcohol-free and drug-free work environment.



Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. #LI-SP1

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